Located in the south of Mendoza, this region is conformed by departments of San Rafael and General Alvear, and extends at the foot of the principal hill. It is an oasis irrigated by the waters of the rivers Atuel and Diamante. The region ranges from 800 meters altitud, above sea level, in San Rafael, up to 450 meters in General Alvear. In this region there are a total of 22 thousand has. implanted, with approximately 200 wineries. That is because San Rafael is considered the second department of the province as far as wine production, and with General Alvear, they make up 18% of the total area planted with vineyards in Mendoza
The qualities of soil and climate favor the cultivation of all varieties: Malbec, Cabernet Sauvignon, Merlot, and in recent times also Sangiovese, Syrah and Bonarda, the last was acknowledged as the most important red grape. Among white grapes are highlighted Chenin Blanc , Semillon and Torrontés, used to make sparkling wines, in addition to Chardonnay.
Tourism in the region has also become important in recent times given the presence of dikes that promotes the practice of activities such as rafting, kayaking and fishing for rainbow trout.