Formed by the departments of San Martín, Junín, Santa Rosa, La Paz, and Rivadavia, represents the largest wine region in the country as it has about 70 thousand hectares dedicated to this activity. The area is characterized by a plain bathed by the waters of Tunuyán River and part of the Mendoza River. This kind of winemaking is plain at an altitude between 750, in the higher elevations, and 650 meters above sea level. The predominant varieties in this area are Chanin Blanc, Malbec, Bonarda, Tempranillo, Merlot and Syrah.
Here are also developed other activities like olivícolas, frutihortícola and beekeeping.